Picks will lock in 2010-09-09 18:30:00 GMT-07:00
| Week 1 | |
| Week: 1 - 2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - 10 - 11 - 12 - 13 - 14 - 15 - 16 - 17 Wild Card - Divisional - Conference - Super Bowl XLV Full Schedule | |
| DATE | GAME |
| Thursday, Sep 09, 2010 | Minnesota Vikings (0 - 0) vs. New Orleans Saints (0 - 0) |
| Sunday, Sep 12, 2010 | Miami Dolphins (0 - 0) vs. Buffalo Bills (0 - 0) |
| Sunday, Sep 12, 2010 | Detroit Lions (0 - 0) vs. Chicago Bears (0 - 0) |
| Sunday, Sep 12, 2010 | Oakland Raiders (0 - 0) vs. Tennessee Titans (0 - 0) |
| Sunday, Sep 12, 2010 | Cincinnati Bengals (0 - 0) vs. New England Patriots (0 - 0) |
| Sunday, Sep 12, 2010 | Carolina Panthers (0 - 0) vs. New York Giants (0 - 0) |
| Sunday, Sep 12, 2010 | Atlanta Falcons (0 - 0) vs. Pittsburgh Steelers (0 - 0) |
| Sunday, Sep 12, 2010 | Cleveland Browns (0 - 0) vs. Tampa Bay Buccaneers (0 - 0) |
| Sunday, Sep 12, 2010 | Denver Broncos (0 - 0) vs. Jacksonville Jaguars (0 - 0) |
| Sunday, Sep 12, 2010 | Indianapolis Colts (0 - 0) vs. Houston Texans (0 - 0) |
| Sunday, Sep 12, 2010 | San Francisco 49ers (0 - 0) vs. Seattle Seahawks (0 - 0) |
| Sunday, Sep 12, 2010 | Green Bay Packers (0 - 0) vs. Philadelphia Eagles (0 - 0) |
| Sunday, Sep 12, 2010 | Arizona Cardinals (0 - 0) vs. St. Louis Rams (0 - 0) |
| Sunday, Sep 12, 2010 | Dallas Cowboys (0 - 0) vs. Washington Redskins (0 - 0) |
| Monday, Sep 13, 2010 | Baltimore Ravens (0 - 0) vs. New York Jets (0 - 0) |
| Monday, Sep 13, 2010 | San Diego Chargers (0 - 0) vs. Kansas City Chiefs (0 - 0) |