Picks will lock in 2010-09-09 18:30:00 GMT-07:00
| Week 4 | |
| Week: 1 - 2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - 10 - 11 - 12 - 13 - 14 - 15 - 16 - 17 Wild Card - Divisional - Conference - Super Bowl XLV Full Schedule | |
| DATE | GAME |
| Sunday, Oct 03, 2010 | San Francisco 49ers (0 - 0) vs. Atlanta Falcons (0 - 0) |
| Sunday, Oct 03, 2010 | New York Jets (0 - 0) vs. Buffalo Bills (0 - 0) |
| Sunday, Oct 03, 2010 | Cincinnati Bengals (0 - 0) vs. Cleveland Browns (0 - 0) |
| Sunday, Oct 03, 2010 | Detroit Lions (0 - 0) vs. Green Bay Packers (0 - 0) |
| Sunday, Oct 03, 2010 | Denver Broncos (0 - 0) vs. Tennessee Titans (0 - 0) |
| Sunday, Oct 03, 2010 | Seattle Seahawks (0 - 0) vs. St. Louis Rams (0 - 0) |
| Sunday, Oct 03, 2010 | Carolina Panthers (0 - 0) vs. New Orleans Saints (0 - 0) |
| Sunday, Oct 03, 2010 | Baltimore Ravens (0 - 0) vs. Pittsburgh Steelers (0 - 0) |
| Sunday, Oct 03, 2010 | Houston Texans (0 - 0) vs. Oakland Raiders (0 - 0) |
| Sunday, Oct 03, 2010 | Indianapolis Colts (0 - 0) vs. Jacksonville Jaguars (0 - 0) |
| Sunday, Oct 03, 2010 | Arizona Cardinals (0 - 0) vs. San Diego Chargers (0 - 0) |
| Sunday, Oct 03, 2010 | Washington Redskins (0 - 0) vs. Philadelphia Eagles (0 - 0) |
| Sunday, Oct 03, 2010 | Chicago Bears (0 - 0) vs. New York Giants (0 - 0) |
| Monday, Oct 04, 2010 | New England Patriots (0 - 0) vs. Miami Dolphins (0 - 0) |