Picks will lock in 2010-09-09 18:30:00 GMT-07:00
San Francisco 49ers
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| 2010 Schedule | |||
| WEEK | DATE | OPPONENT | RESULT |
| 1 | Sunday, Sep 12, 2010 | @ SEA | |
| 2 | Monday, Sep 20, 2010 | vs. NO | |
| 3 | Sunday, Sep 26, 2010 | @ KC | |
| 4 | Sunday, Oct 03, 2010 | @ ATL | |
| 5 | Sunday, Oct 10, 2010 | vs. PHI | |
| 6 | Sunday, Oct 17, 2010 | vs. OAK | |
| 7 | Sunday, Oct 24, 2010 | @ CAR | |
| 8 | Sunday, Oct 31, 2010 | vs. DEN | |
| 9 | BYE | ||
| 10 | Sunday, Nov 14, 2010 | vs. STL | |
| 11 | Sunday, Nov 21, 2010 | vs. TB | |
| 12 | Monday, Nov 29, 2010 | @ ARI | |
| 13 | Sunday, Dec 05, 2010 | @ GB | |
| 14 | Sunday, Dec 12, 2010 | vs. SEA | |
| 15 | Thursday, Dec 16, 2010 | @ SD | |
| 16 | Sunday, Dec 26, 2010 | @ STL | |
| 17 | Sunday, Jan 03, 2010 | vs. ARI | |
